Preheat oven to 375°F (190°C) and line a 12-cup muffin tin with paper liners.
In a large mixing bowl, whisk together the flour, sugar, baking powder, and salt.
In a medium bowl, combine the milk, melted butter, egg, lemon zest, lemon juice, and vanilla extract.
Pour the wet ingredients into the dry ingredients and stir with a spatula until just moistened; do not overmix.
Gently fold the blueberries into the batter.
Distribute the batter evenly into the prepared muffin tin, filling each cup about three-quarters full.
Bake for 18 to 22 minutes, or until a toothpick inserted into the center of a muffin comes out clean.
Remove from oven and let cool in the pan for 5 minutes before transferring to a wire rack.